Crossopteryx is a monotypic genus of flowering plants in the Rubiaceae family. The genus contains only one species, viz. Crossopteryx febrifuga, which is found . Crossopteryx febrifuga. Rubiaceae. (G. Don.) Benth. Crossopteryx febrifuga (Paul Latham). Crossopteryx febrifuga flower and fruit (Paul. Latham). Preparations of Crossopteryx febrifuga (Afzel.) Benth. (Rubiaceae) are widely used in Northern Nigeria in the therapeutic management of.

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Misoprostol a synthetic analogue of prostaglandin E1 completely protected the mucosal layer against piroxicam-induced lceration.

Flavonoids have attracted the attention of many researchers because of their wide range of biological activities Lewis and Hanson,including antiulcer properties La Casa et al. Please review our privacy policy. In addition the observed gastro-protective effect of the extract may be related to effects of several classes of active secondary compounds present in this medicinal plant.

Preparations of the tree is used traditionally for symptomatic relief of dry cough and for treatment of septic wounds, respiratory infections, fever, dysentery and pain. Fbrifuga can thus be developed as a safe alternative to conventional non-steroidal anti-inflammatory drugs NSAIDs for the management of painful inflammatory disorders.

Flora of Zimbabwe: Species information: individual images: Crossopteryx febrifuga

Chemical and Pharmaceutical Bulletin. The technical assistance of the Staff of Animal Facility center is highly appreciated. The lesions observed were assessed for the following; mucosal atrophy, presence of inflammatory cells in the wall, eosinophils, lymphocytes and plasma cells. Nonsteroidal anti-inflammatory drugs NSAIDswhich act as non-selective cyclooxygenase COX inhibitors, are commonly used to treat pain and inflammation despite the risk of major upper gastrointestinal complications Venkova et al.


These rats were also observed for signs of toxicity and mortality for the first critical 4h and thereafter daily for 7 days. Pharmacological studies of Panacis japonici Rhizoma.

A saponin with anti-ulcerogenic effect from the flowers of Spartium junceum. One hour after ethanol administration, the rats were sacrificed under diethyl ether anaesthesia. The efficacy of the gastro-histoprotective effects of methanolic extract of Crossopteryx febrifuga against the piroxicam – induced gastric mucosa atrophy and ethanol-induced focal infiltration of inflammatory cells croesopteryx mucosa areas, crossoptetyx comparable to that of misoprostol and cimetidine respectively.

Open in a separate window. Materials and Methods Fsbrifuga plant material Fresh stem bark of C. In northern Nigeria, the plant has been used for treatment of pain and malaria for many years and its efficacy has been established in our laboratory Salawu et al. Indian J Fevrifuga Pharmacol. Photomicrographs of representative lesions were taken at various magnifications. The products of the 5-lipoxygenase pathway may also play a key role in the development of ulcer induced by irritant agents such as ethanol Lange et al.

Anti-ulcer drugs of plant origin. Antiulcerogenic activity of aescine in different experimental models. In the present study, crossoptery methanolic stem bark extract of Crossopteryx febrifuga was evaluated against ethanol- and piroxicam-induced ulceration in rats.

Acute toxicity LD50 study The oral median lethal dose LD 50 of the methanolic extract was determined in rats orally using Lorke’s method with modifications. Effects of the extract on ethanol-induced gastric ulceration Ethanol produced haemorrhagic gastric lesions mainly in the glandular segment of the stomach mucosa.


Crossopteryx febrifuga

Relation to gastric hypermotility. This class of secondary compounds is able to protect the gastric mucosa against a variety of antiulcerogenic agents, particularly through scavenging properties on oxygen radicals by inhibition of nitric oxide Synthase activity Di Carlo et al. Abstract Preparations of Crossopteryx febrifuga Afzel. The present study was therefore designed to study its effect on the gastrointestinal tract when used for management of chronic pain related disorders.

Crossopteryx febrifuga, extract, analgesic, anti-inflammatory agents, gastrointestinal tract, ulcer. The stomachs were removed, opened along the greater curvature, rinsed with slow running water.

The phytochemical analyses carried out on methanolic stem bark extract of Crossopteryx febrifuga by Salawu et al.

Gastro-Protective Effect of Crossopteryx Febrifuga in Wistar Rats

Ethanol-induced gastric ulceration The method described by Salawu et al. The resultant mixture was filtered using Whatman filter paper No. Finally, the flavonoids are the major secondary metabolites class with several descriptions of antiulcer, antioxidant and gastroprotective properties, which involves nitric oxide participation Matsuda et al. Effect of the extract on piroxicam-induced gastric ulceration Piroxicam produced focal haemorrhagic gastric lesions and inflammation of the stomach mucosa in the rats.

Histologic and microcirculatory changes in febrofuga gastric lesions in the rats: Piroxicam-induced gastric ulceration The method described by Salawu et al.